Compassionate Use: Severe Covid-19

During a median follow-up of 18 days
In addition, we evaluated the proportion of patients with clinical improvement, as defined by live discharge from a decrease of at least 2 points from baseline on a modified ordinal scale (as recommended by the WHO R&D Blueprint Group), or both
The six-point scale consists of the following categories: 1, not hospitalized; 2, hospitalized, not requiring supplemental oxygen; 3, hospitalized, requiring supplemental oxygen; 4, hospitalized, requiring nasal high-flow oxygen therapy, noninvasive mechanical ventilation, or both; 5, hospitalized, requiring invasive mechanical ventilation, ECMO, or both; and 6, death.
Overall safety summary
- Graded elevations in ALT and AST have been observed ,the mechanism of these elevations is unknown
- Patients should have appropriate clinical and laboratory monitoring to aid in early detection of any potential adverse events.